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Formation and reduction of glutathione-protein mixed disulfides during oxidative stress

This may be partly due to lower total antioxidant activity in these patients, particularly the decrease in SOD and CAT activities (24, 25)

The adverse effects of diabetes extend beyond the endothelium, as hyperglycemic conditions impact microglia activation, leading to increased proinflammatory cytokine production and ROS formation in both the endothelium and parenchymal microglia

17 Possible reasons for doctors not prescribing oral formulations may include a of this option or lack of awareness

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